Tetrahedron letters

Chlorotrimethylsilane promoted asymmetric Michael reaction of chiral enamines of α-alkyl β-keto esters

K Tomioka, W Seo, K Ando, K Koga

Index: Tomioka, Kiyoshi; Seo, Wonjun; Ando, Kaori; Koga, Kenji Tetrahedron Letters, 1987 , vol. 28, # 52 p. 6637 - 6640

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Citation Number: 33

Abstract

Abstract By the promotion of chlorotrimethylsilane, asymmetric Michael reaction of the chiral enamines (2) of α-alkyl β-keto esters (1) with methyl vinyl ketone and ethyl acrylate proceeded to afford, after hydrolysis, either enantiomer of the corresponding adducts (4) in a good enantioselectivity.

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