… Indonesian marine sponge Lamellodysidea herbacea and its chemical derivatives inhibit protein tyrosine phosphatase 1B, an important target for diabetes treatment

…, H Rotinsulu, DS Wewengkang, M Ishikawa…

Index: Yamazaki, Hiroyuki; Sumilat, Deiske A.; Kanno, Syu-Ichi; Ukai, Kazuyo; Rotinsulu, Henki; Wewengkang, Defny S.; Ishikawa, Masaaki; Mangindaan, Remy E. P.; Namikoshi, Michio Journal of Natural Medicines, 2013 , vol. 67, # 4 p. 730 - 735

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Citation Number: 24

Abstract

Abstract The ethanol extract of an Indonesian marine sponge Lamellodysidea herbacea inhibited the activity of protein tyrosine phosphatase 1B (PTP1B), an important target enzyme for the treatment of type II diabetes. Bioassay-guided isolation yielded a known polybromodiphenyl ether (1) as a sole bioactive component. The structure of 1 was confirmed by spectroscopic data for 1 and its methyl ether derivative (2). Compound 1 ...