Total synthesis of the tylophora alkaloids rusplinone, 13aα-secoantofine, and antofine using a multicatalytic oxidative aminochlorocarbonylation/Friedel–Crafts …
LM Ambrosini, TA Cernak, TH Lambert
Index: Ambrosini, Lisa M.; Cernak, Tim A.; Lambert, Tristan H. Tetrahedron, 2010 , vol. 66, # 26 p. 4882 - 4887
Full Text: HTML
Citation Number: 16
Abstract
A rapid synthetic approach to the tylophora alkaloids antofine and 13aα-secoantofine is presented that makes use of a multicatalytic oxidative aminochlorocarbonylation/Friedel– Crafts reaction as the key step. This reaction, along with a one-pot, three-step telescoped process offers a three or four-pot sequence to access the title compounds in high overall yield.
Related Articles:
[Couture; Deniau; Grandclaudon; Lebrun Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7749 - 7752]
[Brown, Dearg S.; Charreau, Philippe; Hansson, Thomas; Ley, Steven V. Tetrahedron, 1991 , vol. 47, # 7 p. 1311 - 1328]
[Couture; Deniau; Grandclaudon; Lebrun Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7749 - 7752]
[Couture; Deniau; Grandclaudon; Lebrun Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7749 - 7752]
[Brown, Dearg S.; Charreau, Philippe; Hansson, Thomas; Ley, Steven V. Tetrahedron, 1991 , vol. 47, # 7 p. 1311 - 1328]