Synthesis and first in vivo evaluation of new selective high affinity β 1-adrenoceptor radioligands for SPECT based on ICI 89,406

…, B Riemann, VW Pike, O Schober, M Schäfers

Index: Wagner, Stefan; Kopka, Klaus; Law, Marilyn P.; Riemann, Burkhard; Pike, Victor W.; Schober, Otmar; Schaefers, Michael Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4117 - 4132

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Citation Number: 16

Abstract

The results of cardiac biopsies suggest that myocardial β1-adrenoceptor (AR) density is reduced in patients with chronic heart failure, while changes in cardiac β2-ARs vary. A technique for visualization and quantification of β1-AR populations rather than total β-AR densities in the human heart would be of great clinical interest. Molecular imaging techniques, either single photon emission computed tomography (SPECT) or positron ...