New monofunctional reagents for DNA as possible agents for the photochemotherapy of psoriasis: derivatives of 4, 5'-dimethylangelicin
F Dall'Acqua, D Vedaldi, S Caffieri…
Index: Dall'Acqua; Vedaldi; Caffieri; Guiotto; Rodighiero; Baccichetti; Carlassare; Bordin Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 178 - 184
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Citation Number: 49
Abstract
Results Chemistry. 4'-(Hydroxymethyl)-4, 5'-dimethylangelicin (3), 4'-(methoxymethyl)-4, 5'~ ethylangelicin (4), and the hydrochloride of 4'-(aminomethyl)-4, 5'-dimethylangelicin (5) have been prepared from 2 according to the synthetic procedure of Isaacs et al. 12 The tritiated compounds 3-5 have been prepared by substituting, in an analogous way as for unlabeled compounds, hydroxymethyl, methoxymethyl, or aminomethyl groups on tritiated ...
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