Synthesis of 3??Acyl??1, 2??benzisoxazoles

T Yamamori, Y Hiramatsu…

Index: Yamamori, Teruo; Hiramatsu, Yoshiharu; Adachi, Ikuo Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 347 - 350

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Citation Number: 6

Abstract

Abstract A convenient method for the synthesis of 3-acyl-1, 2-benzisoxazoles, which are unstable toward bases, is described. Base-catalyzed cyclization of 2-alkyl-and aryl-1, 3- dithian-2-yl o-chlorophenylketoximes 4a-1 gave 3-(2-alkyl-and aryl-1, 3-dithian-2-yl)-1, 2- benzisoxazoles 8a-1, which were converted into the corresponding 3-acyl-1, 2- benzisoxazoles 1a-1.

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