Synthesis of 7-oxo-3-oxa-1-azabicyclo [3.2. 0] heptane-2-carboxylates: analogues of clavulanic acid

J Brennan, G Richardson, RJ Stoodley

Index: Brennan, John; Richardson, Geoffrey; Stoodley, Richard J. Journal of the Chemical Society, Chemical Communications, 1980 , # 2 p. 49

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Abstract

By JOHN BRENNAN, GEOFFREY RICHARDSON, and RICHARD J STOODLEY* (Department of Organzc Chemzstry, The Unzverszty, Newcastle upon Tyne NE 1 7RU) Summary 4-Iodomethylazetidin-2-one is converted into the title compounds when treated sequentially with glyoxylic acid esters and sodium hydride ... THE disclosure that clavulanic acid (l), a metabolite of Streptowzyces clavuZzgerus,l is a potent irreversible inhibitor of a wide range of ...