Tetrahedron

Catalytic enantioselective dehydrogenative Si–O coupling of oxime ether-functionalized alcohols

A Weickgenannt, J Mohr, M Oestreich

Index: Weickgenannt, Andreas; Mohr, Jens; Oestreich, Martin Tetrahedron, 2012 , vol. 68, # 17 p. 3468 - 3479

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Citation Number: 9

Abstract

Asymmetric silylation of alcohols is an unusual but effective approach to their kinetic resolution, and the Cu–H-catalyzed dehydrogenative Si–O coupling is particularly noteworthy as dihydrogen is formed as the sole by-product. Our laboratory had previously reported on diastereoselective (with silicon-stereogenic silanes) and enantioselective (with achiral silanes) Si–O couplings of azine donor-functionalized alcohols. The limitation, that ...