Pancreatic α-amylase inhibition and free radical scavenging activity of substituted pyranochromenone derivatives

JA Kumar, AK Tiwari, G Saidachary, C Kishor…

Index: Ashok Kumar; Tiwari, Ashok K.; Saidachary; Kishor, Chandan; Kumar, D. Anand; Ali, Zehra; Sridhar; Addlagatta, Anthony; Raju, B. China Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 2821 - 2833

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Citation Number: 3

Abstract

Abstract Pyranochromenone derivatives 3a–d, 6a–j and 2 H-chromenones 8a–b were synthesized and screened for their in vitro α-amylase inhibitory and ABTS•+[2, 2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)] free radical scavenging activities. Compounds 3a, 3c, and 6d displayed dual function of ABTS•+ radical scavenging as well as α-amylase inhibition. Compound 6h was found to be most potent α-amylase inhibitor in present ...