The Journal of organic chemistry

An Efficient Synthesis of a Furan-Side Furocoumarin Thymidine Monoadduct

WR Kobertz, JM Essigmann

Index: Kobertz, William R.; Essigmann, John M. Journal of Organic Chemistry, 1997 , vol. 62, # 8 p. 2630 - 2632

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Citation Number: 13

Abstract

The construction of oligonucleotides containing a modified nucleoside at a predefined site has provided new insights into the mechanisms of DNA repair and mutagenesis. 1 Organic chemists have played a key role by synthesizing nucleosides damaged by UV and ionizing radiation, chemical carcinogens, and chemotherapeutic agents. 2 Further incorporation of these modified nucleosides into oligonucleotides has enabled the direct study of ...