Oxidative Bromination in a Liquid-Liquid Two-Phase System to Synthesize Organic Intermediates: 2-Bromophenol, 2, 6-Dibromophenol, and 2-Bromo-4-methylphenol
S Mukhopadhyay, S Ananthakrishnan…
Index: Mukhopadhyay, Sudip; Ananthakrishnan; Chandalia, Sampatraj B. Organic Process Research and Development, 1999 , vol. 3, # 6 p. 451 - 454
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Citation Number: 16
Abstract
An alternative manufacturing process-scheme was developed to synthesize 2-bromophenol and 2, 6-dibromophenol involving oxidative bromination of a substrate protected in the para position in a two-phase system followed by deprotection involving decarboxylation. Thus, selective oxidative bromination of 4-hydroxybenzoic acid in ethylenedichloride with HBr- H2O2, and subsequent decarboxylation in quinoline gave 90-95% yield to the mono-or ...
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