Tetrahedron letters

A multicomponent reaction efficiently producing arylmethylene 2-thiohydantoins

S Porwal, R Kumar, PR Maulik, PMS Chauhan

Index: Porwal, Sharad; Kumar, Rishi; Maulik, Prakas R.; Chauhan, Prem M.S. Tetrahedron Letters, 2006 , vol. 47, # 33 p. 5863 - 5866

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Citation Number: 23

Abstract

We describe here a multicomponent reaction that converts aryl/heteroaryl aldehydes efficiently into arylmethylene 2-thiohydantoins. 3-Formylindole behaves exceptionally giving a gem-diacetylthio derivative. A mechanistic study of the behaviour of 3-formylindole, which provides a new class of indole derivative, is described.