Tetrahedron

New heteroaromatic aminations on 5-aryl-1, 2, 4-triazines and 1, 2, 4, 5-tetrazines by palladium catalysis

L Pellegatti, E Vedrenne, JM Leger, C Jarry, S Routier

Index: Pellegatti, Laurent; Vedrenne, Emeline; Leger, Jean-Michel; Jarry, Christian; Routier, Sylvain Tetrahedron, 2010 , vol. 66, # 24 p. 4383 - 4389

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Citation Number: 11

Abstract

The efficient and original palladium-catalyzed amination of 5-Aryl-1, 2, 4-triazines and 1, 2, 4, 5-tetrazines is reported. This Buchwald–Hartwig type reaction leads to the formation of aminated heterocycles via methylsulfur release. The reaction is optimized and a wide range of amines is used to determine the scope and limitations of this methodology.

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