Development and characterization of a potent free fatty acid receptor 1 (FFA1) fluorescent tracer

E Christiansen, BD Hudson, AH Hansen…

Index: Christiansen, Elisabeth; Due-Hansen, Maria E.; Urban, Christian; Merten, Nicole; Pfleiderer, Michael; Karlsen, Kasper K.; Rasmussen, Sanne S.; Steensgaard, Mette; Hamacher, Alexandra; Schmidt, Johannes; Drewke, Christel; Petersen, Rasmus Koefoed; Kristiansen, Karsten; Ullrich, Susanne; Kostenis, Evi; Kassack, Matthias U.; Ulven, Trond ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 7 p. 345 - 349

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Citation Number: 6

Abstract

The free fatty acid receptor 1 (FFA1/GPR40) is a potential target for treatment of type 2 diabetes. Although several potent agonists have been described, there remains a strong need for suitable tracers to interrogate ligand binding to this receptor. We address this by