Differential antiproliferative activity of new benzimidazole-4, 7-diones
L Garuti, M Roberti, D Pizzirani, A Pession, E Leoncini…
Index: Garuti, Laura; Roberti, Marinella; Pizzirani, Daniela; Pession, Annalisa; Leoncini, Emanuela; Cenci, Valentina; Hrelia, Silvana Farmaco, 2004 , vol. 59, # 8 p. 663 - 668
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Citation Number: 31
Abstract
Ten benzimidazole-4, 7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.
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