Synthesis and anticancer activity of 5-(1, 2-diselenolan-3-yl) pentanoic acid and its derivatives

F Xu, ZZ Yang, SJ Zhang

Index: Xu, Feng; Yang, Zhen-Zhen; Zhang, Shi-Jie Phosphorus, Sulfur and Silicon and the Related Elements, 2013 , vol. 188, # 10 p. 1312 - 1319

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Abstract

A green and high-yielding synthetic route for the preparation of 5-(1,2-diselenolan-3-yl)pentanoic acid (SeA) was reported. Some SeA derivatives, N′-substituted benzylidene-5-(1,2-diselenolan -3-yl)pentanehydrazide, were prepared, and they were screened for their anticancer activity against human breast MCF-7, leukemia HL-60, cervixuterus Hela, and placental villus Bewo cancer cell lines. The minimum inhibitory concentrations (MICs) of the synthetic compounds showed ...