Benzo [f] azino [2, 1-a] phthalazinium cations: novel DNA intercalating chromophores with antiproliferative activity

…, C Burgos, J Alvarez-Builla, G Fernández…

Index: Martinez, Valentin; Burgos, Carolina; Alvarez-Builla, Julio; Fernandez, Geronimo; Domingo, Alberto; Garcia-Nieto, Raquel; Gago, Federico; Manzanares, Ignacio; Cuevas, Carmen; Vaquero, Juan J. Journal of Medicinal Chemistry, 2004 , vol. 47, # 5 p. 1136 - 1148

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Citation Number: 37

Abstract

New azaquinolizinium-type cations have been obtained from isochromane. The synthesis was completed over seven steps and included as the key feature an intramolecular Westphal condensation. This first example of the intramolecular process allowed the preparation of benzo [f] pyrido [2, 1-a] phthalazinium and benzo [f] quino [2, 1-a] phthalazinium salts, which were evaluated as DNA intercalators, DNA topoisomerase I ...