Angewandte Chemie International Edition

The First General Method for Stille Cross??Couplings of Aryl Chlorides

AF Littke, GC Fu

Index: Littke, Adam F.; Fu, Gregory C. Angewandte Chemie - International Edition, 1999 , vol. 38, # 16 p. 2411 - 2413

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Citation Number: 292

Abstract

Abstract A “one-two punch” comprising two commercially available reagents, PtBu 3 and CsF, provides a practical and general solution for a long-standing limitation of the Stille reaction—the inability to couple inexpensive and readily available aryl chlorides [Eq.(1); R 1= OMe, NH 2, o-Me, etc.; R= vinyl, allyl, Ph, Bu, etc.].

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