New amidino-benzimidazolyl derivatives of tylosin and desmycosin.

…, S Mutak, M Derek, G Karminski-Zamola

Index: Hranjec, Marijana; Starcevic, Kristina; Zamola, Branimir; Mutak, Stjepan; Derek, Marko; Karminski-Zamola, Grace Journal of Antibiotics, 2002 , vol. 55, # 3 p. 308 - 314

Full Text: HTML

Citation Number: 14

Abstract

New amidino-benzimidazolyl derivatives of antibiotics tylosin and desmycosin are prepared in the reaction of corresponding amidino-substituted o-phenylendiamine with tylosin respectively desmyicosin on the 20-C aldehyde group. The reaction was carried out in absolute ethanol in the presence of p-benzoquinone. On this way are prepared: 20-[5-(N- isopropylamidino)-2-benzimidazolyl] tylosin hydrochloride 9, 20-[5-(2-imidazolinyl)-2- ...