Selective terminal Heck arylation of vinyl ethers with aryl chlorides: a combined experimental-computational approach including synthesis of betaxolol
…, H von Schenck, A Hallberg, M Larhed
Index: Datta, Gopal K.; Von Schenck, Henrik; Hallberg, Anders; Larhed, Mats Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3896 - 3903
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Citation Number: 76
Abstract
Reaction conditions have been developed for palladium-catalyzed terminal (β-) arylation of acyclic vinyl ethers with high regioselectivity using inexpensive aryl chlorides as starting materials and the P (t-Bu) 3 releasing preligand [(t-Bu3) PH] BF4 as the key additive. This swift and straightforward protocol exploits non-inert conditions and controlled microwave heating to minimize handling and processing times and uses aqueous DMF or ...
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