Chemical Communications

Synthesis and reactivity of enediynyl amino acids and peptides: a novel concept in lowering the activation energy of Bergman cyclisation by H-bonding and …

A Basak, SS Bag, HMM Bdour

Index: Basak, Amit; Bag, Subhendu Sekhar; Bdour, Hussam M M Chemical communications (Cambridge, England), 2003 , # 20 p. 2614 - 2615

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Citation Number: 15

Abstract

Novel enediynyl amino acids and peptides 3 and 5–8 were synthesized and their thermal reactivity towards Bergman cyclization studied and compared with the earlier reported amino acid 4, which demonstrated, for the first time, the effect of H-bonding and electrostatic interactions in lowering the activation energy of Bergman cyclization.