Bulky amine analogs of ketoprofen: potent antiinflammatory agents

…, BL Zenitz, CA Fellows, SC Laskowski…

Index: Schlegel; Zenitz; Fellows; Laskowski; Behn; Phillips; Botton; Speight Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1682 - 1690

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Citation Number: 13

Abstract

Replacement of the carboxyl group of 2-(3-benzoylphenyl) propionic acid (Ketoprofen) with various bulky amines has produced a series of highly active antiinflammatory agents that have reduced intestinal ulcerogenicity and have better therapeutic ratios in the 21-day adjuvant arthritis assay in rats than currently marketed nonsteroidal antiinflammatory drugs. Activity is maintained on reduction of these 2-(3-benzoylphenyl) propyl bulky amines to ...