One-pot synthesis of 4-aminoquinazolines by hexamethyldisilazane-mediated reaction of quinazolin-4 (3 H)-ones with amines

ZL Shen, XF He, YM Hong, XQ Hu, WM Mo…

Index: Shen, Zhen-Lu; He, Xiao-Fei; Hong, Yi-Ming; Hu, Xin-Quan; Mo, Wei-Min; Hu, Bao-Xiang; Sun, Nan Synthetic Communications, 2011 , vol. 41, # 24 p. 3644 - 3653

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Abstract

Abstract Hexamethyldisilazane-mediated reaction of quinazolin-4 (3 H)-ones with primary amines led to facile formation of 4-aminoquinazolines through tandem silylation and substitution in a single pot. Excellent yields of the products (83–97%) and environmental friendliness (avoiding the use of chlorination reagents) are the advantages of this method.