4, 5-Dihydro-3-(methanesulfonamidophenyl)-1-phenyl-1H-2, 4-benzodiazepines: A novel class III antiarrhythmic agents

…, P Canniff, PM Carabateas, T D'Ambra…

Index: Johnson; Silver; Becker; Birsner; Bohnet; Briggs; Busacca; Canniff; Carabateas; Chadwick; D'Ambra; Dundore; Dung; Ezrin; Gorczyca; Habeeb; Horan; Krafte; Pilling; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2551 - 2556

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Citation Number: 11

Abstract

A series of 4, 5-dihydro-3-[2-(methanesulfonamidophenyl) ethyll-l-phenyl-~-2, 4- benzodiazepines has been identified as potential antiarrhythmic agents that interact at the delayed rectifier myocardial potassium channels (Id and prolong the ventricular effective refractory period (ERP) in rabbit isolated LangendorfT heart preparations. Structure-activity relationship (SAR) studies based upon prolongation of ERP indicate that placement of the ...