Biochemical pharmacology

Identification of the human cytochromes P450 involved in the oxidative metabolism of “Ecstasy”-related designer drugs

KP Kreth, KA Kovar, M Schwab, UM Zanger

Index: Kreth, Klaus-Peter; Kovar, Karl-Artur; Schwab, Matthias; Zanger, Ulrich M. Biochemical Pharmacology, 2000 , vol. 59, # 12 p. 1563 - 1571

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Citation Number: 218

Abstract

The human cytochrome P450 (CYP) isozymes catalyzing the oxidative metabolism of the widely abused amphetamine derivatives MDMA (N-methyl-3, 4- methylenedioxyamphetamine,“Ecstasy”), MDE (N-ethyl-3, 4-methylenedioxyamphetamine,“ Eve”), and MDA (3, 4-methylenedioxyamphetamine) were identified. Using a simplified non- extractive reversed-phase HPLC assay with fluorescence detection, biphasic Michaelis– ...