Regioselective O2′, O3′??Deacetylations of Peracetylated Ribonucleosides by Using Tetra??n??butylammonium Fluoride

A Babu Kumar, R Manetsch

Index: Babu Kumar, Arun; Manetsch, Roman European Journal of Organic Chemistry, 2014 , vol. 2014, # 17 p. 3551 - 3555

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Abstract

Abstract A robust, mild, and highly regioselective deacetylation of 1, 2-diol diacetates in the presence of other acetate functions was achieved by using tetra-n-butylammonium fluoride. This method provided a single-step route to access O5′-acetyl ribonucleosides, a key intermediate in the synthesis of biomedically important nucleosides and nucleotides. Moreover, it offered the general applicability of a non-enzymatic method for the selective ...

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