Sunthetic Studies of Microsclerodermins. A Stereoselective Synthesis of a Core Building Block for (2 S, 3 R, 4 S, 5 S, 6 S, 11 E)-3-Amino-6-methyl-12-(4- …
S Sasaki, Y Hamada, T Shioiri
Index: Sasaki, Shigekazu; Hamada, Yasumasa; Shioiri, Takayuki Tetrahedron Letters, 1997 , vol. 38, # 17 p. 3013 - 3016
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Citation Number: 32
Abstract
A core building block 3 for (2 S, 3 R, 4 S, 5 S, 6 S, 11 E)-3-amino-6-methyl-12-(4- methoxyphenyl)-2, 4, 5-trihydroxydodec-11-enoic acid (2, AMMTD) has been efficiently synthesized using the Sharpless asymmetric dihydroxylation and the Dondoni's furan addition to a nitrone derivative as key steps. The 2-furyl group has been used as the carboxyl synthon.© 1997 Elsevier Science Ltd.
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