Tetrahedron letters

Separation of pyrrolidine allylation products by diastereoselective enzymatic ester hydrolysis

…, CJ Astle, H Iding, B Wirz, M Rogers-Evans

Index: Aggarwal, Varinder K.; Astle, Christopher J.; Iding, Hans; Wirz, Beat; Rogers-Evans, Mark Tetrahedron Letters, 2005 , vol. 46, # 6 p. 945 - 947

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Citation Number: 18

Abstract

Although enzymes have been used extensively for enantioselective synthesis, they have also occasionally been used in diastereoselective synthesis. 1 In the latter scenario, one diastereomer is transformed by the enzyme leaving the other diastereomer untouched, thus allowing facile separation of the two compounds. We recently encountered a very difficult separation of diastereomers and considered the use of enzymes to solve the problem. In this paper we detail a multi- ...

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