Rapid and Efficient Synthesis of (R)-Aryloxypropionic Acid Esters Under Microwave Irradiation

Z Ochal, K Durka, Ł Banach

Index: Ochal, Zbigniew; Durka, Krzysztof; Banach, Lukasz Synthetic Communications, 2010 , vol. 40, # 21 p. 3209 - 3213

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Abstract

A series of (R)-(+)-ethyl aryloxypropionates (4a–4p) have been synthesized by the reaction of substituted phenols with ethyl (S)-(−)-tosyloxy lactate under the conditions of microwave irradiation and without solvents. The reaction conditions have been optimized. A good method for the preparation of (R)-(+)-ethyl aryloxypropionate was developed, with good yields, high enantiomer excess, short reaction times, easy workup, and simple procedure.