Nucleoside sultones: synthons for the preparation of novel nucleotide analogs. 1. Synthesis and ring-opening reactions
…, RC Reynolds, JA Maddry, A Rathore…
Index: Crooks, Peter A.; Reynolds, Robert C.; Maddry, Joseph A.; Rathore, Anita; Akhtar, M. Shamim; et al. Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2830 - 2835
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Citation Number: 14
Abstract
Treatment of either the 5'-0-tosyl or the 5'-O-mesyl derivative of 3'-O-mesylthymidine with lithium acetylide-ethylenediamine complex in DMSO affords the intramolecular 6, 3-ester of 1, 2, 5, 6-tetradeoxy-l-(3, 4-di-hydro-5 methyl-2, 4 diox~ l (~-pyrimidinyc acid (2). Similarly, the 5'-0-byl or 5'-0-mesyl derivative of 1-(2-deoxy-3-O-mesyl-b-~-threo-pentofuranosy1) thymine affords the intramolecular 6, 3-ester of 1, 2, 5, 6-tetradeoxy-1-(3, 4-dihydro-5- ...
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