Synlett

Parallel synthesis of pyrazolines on soluble polymer support

YG Wang, J Zhang, XF Lin, HF Ding

Index: Wang, Yan-Guang; Zhang, Jian; Lin, Xu-Feng; Ding, Han-Feng Synlett, 2003 , # 10 p. 1467 - 1468

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Citation Number: 15

Abstract

Abstract An efficient and rapid parallel liquid-phase synthesis of pyrazolines has been developed. The one-pot three-components reaction of polyethylene glycol (PEG)-supported acrylate 1, aldehyde 2 and aryl hydrazine 3 in the presence of chloramine-T in methanol gave the corresponding PEG-supported pyrazolines 5. Cleavage from the support under mild conditions afforded pyrazolines 6 in good yields (69-91%) and high purities (91-100 ...