4-(Benzoylindolizinyl) butyric Acids; Novel Nonsteroidal Inhibitors of Steroid 5. ALPHA.-Reductase. III.

K Sawada, S Okada, A Kuroda, S WATANABE…

Index: Sawada; Okada; Kuroda; Watanabe; Tanaka Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 7 p. 799 - 813

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Citation Number: 24

Abstract

A novel series of indolizinebutyric acids with various benzoyl substituents was synthesized to develop nonsteroidal inhibitors of steroid 5α-reductase, and the structure-activity relationships in this series were studied. We previously reported the structure-activity relationships in a series of indolebutyric acids as well as the discovery of the novel nonsteroidal 5α-reductase inhibitor, FK143. We have now made other modifications to this ...