Tetrahedron: Asymmetry

Stereocomplementary asymmetric bioreduction of boron-containing ketones mediated by alcohol dehydrogenases

T Barcellos, K Tauber, W Kroutil, LH Andrade

Index: Barcellos, Thiago; Tauber, Katharina; Kroutil, Wolfgang; Andrade, Leandro H. Tetrahedron Asymmetry, 2011 , vol. 22, # 18-19 p. 1772 - 1777

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Citation Number: 8

Abstract

Optically active boron-containing alcohols were prepared via the stereoselective reduction of the corresponding carbonyl compounds by alcohol dehydrogenases. Depending on the substrate, both (R)-alcohols and (S)-alcohols were obtained with excellent enantioselectivity (up to> 99% ee) employing either ADH-A or LB-ADH.