Cytostatic tetrazole–butenolide conjugates: linking tetrazole and butenolide rings via stille coupling and biological activity of the target substances

…, M Špulák, M Pour, I Votruba, V Buchta

Index: Balsanek, Vojtech; Tichotova, Lucie; Kunes, Jiri; Spulak, Marcel; Pour, Milan; Votruba, Ivan; Buchta, Vladimir Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 7-8 p. 1161 - 1178

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Citation Number: 3

Abstract

Abstract A series of tetrazoles linked to the butenolide core via benzene rings were prepared by the Stille coupling reaction of α-(tributylstannyl) butenolides and 5-(alkylsulfanyl)-1-(4- iodophenyl) tetrazoles, and the compounds were tested for antifungal and cytostatic activity. Interesting antifungal activities against the filamentous strain Absidia corymbifera, and cytostatic activities against leukemic cells HL-60 and CCRF-CEM were found. The ...