Stereoselective Synthesis of 2', 3'-Dideoxy-3'-fluoro-2'-phenylselenenyl-β-nucleosides from Phenyl 1-Seleno-α-arabino-furanosides through Consecutive 1, 2- …
N Poopeiko, R Fernández, MI Barrena…
Index: Poopeiko; Fernandez; Barrena; Castillon; Fornies-Camer; Cardin Journal of Organic Chemistry, 1999 , vol. 64, # 4 p. 1375 - 1379
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Citation Number: 30
Abstract
2′, 3′-Dideoxy-3′-fluoronucleosides are among the most potent antiviral drugs1 avalaible, and 3′-deoxy-3′-fluorothymidine (FLT) in particular is an efficient agent against HIV viruses. 2 Consequently, much attention has been devoted to the preparation of different 3′-deoxy-3′-fluoronucleosides with additional modifications in the sugar ring or in the base. Two general methods are used to prepare these compounds:(a) fluorinating ...
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