Tetrahedron

Improved nickel-catalyzed cross-coupling reaction conditions between ortho-substituted aryl iodides/nonaflates and alkylzinc iodides in solution and in the solid- …

AE Jensen, W Dohle, P Knochel

Index: Jensen, Anne Eeg; Dohle, Wolfgang; Knochel, Paul Tetrahedron, 2000 , vol. 56, # 25 p. 4197 - 4201

Full Text: HTML

Citation Number: 30

Abstract

The palladium or nickel-catalyzed cross-coupling reaction between organometallic reagents and organic halides is an important method for preparing polyfunctional molecules. 1 Especially useful is the cross-coupling between aryl halides and alkyl organometallics. In this respect, the Negishi-cross-coupling reaction using alkylzinc halides has given excellent results. 2. and 3. Unfortunately, this palladium-catalyzed cross-coupling leads to poor reactions in the solid- ...