Efficient Solvent-Free Knoevenagel Condensation Between β-Diketone and Aldehyde Catalyzed by Silica Sulfuric Acid

F Zhang, YX Wang, FL Yang, HY Zhang…

Index: Zhang, Fuyi; Wang, Yu-Xin; Yang, Feng-Ling; Zhang, Hong-Yu; Zhao, Yu-Fen Synthetic Communications, 2011 , vol. 41, # 3 p. 347 - 356

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Citation Number: 11

Abstract

Silica sulfuric acid has been utilized as an efficient heterogeneous recyclable catalyst for Knoevenagel condensation between poorly reactive β-diketones and aldehydes under solvent-free conditions. This protocol also works well with more reactive β-ketoesters. The condensation is efficient, clean, and mild. The scope and generality of the Knoevenagel condensation were investigated. The procedure led only to the Knoevenagel product, and ...