Comparison of the hypolipidemic activity of cyclic vs. acyclic imides

PJ Voorstad, JM Chapman, GH Cocolas…

Index: Voorstad; Chapman; Cocolas; Wyrick; Hall Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 9 - 12

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Citation Number: 14

Abstract

Two series of nitrogen-substituted cyclic and acyclic imides were examined for hypolipidemic activity in mice after dosing for 16 days at a dose of 20 mg/kg per day. The hypolipidemic activity of the unsubstituted, N-butyl, N-3-oxobuty1, and N-2-carboxyethyl derivatives of diacetimide and succinimide were compared as well as the unsubstituted and N-substituted dibenzimide and diphenimide. It was shown that an imide functionality ...