A Machine??Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor??1

C Battilocchio, BJ Deadman, N Nikbin…

Index: Battilocchio, Claudio; Deadman, Benjamin J.; Nikbin, Nikzad; Kitching, Matthew O.; Baxendale, Ian R.; Ley, Steven V. Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7917 - 7930

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Citation Number: 33

Abstract

Abstract Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not ...