Total synthesis of pyrrolizidines 223H′, 239K′, 265H′, and 267H′ found in Madagascan frogs (Mantella) and their affinities for nicotinic acetylcholine receptor

H Takahata, S Takahashi, N Azer, AT Eldefrawi…

Index: Takahata, Hiroki; Takahashi, Seiki; Azer, Nehad; Eldefrawi, Amira T.; Eldefrawi, Mohyee E. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 11 p. 1293 - 1295

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Citation Number: 14

Abstract

Amphibian skin has provided a wide range of biologically active alkaloids. During the past 30 years, over 400 alkaloids of over 20 structural classes have been detected. 1 Recently, four 3,5-disubstituted pyrrolizidines 223H′, 239K′, 265H′, and 267H′ were isolated in Madagascan frogs (Mantella) 2 . Among them, it is known the relative structure of pyrrolizididine 223H′ is identical with that of xenovenine found in ant (Solenopsis xenoveneum). 3 So far, the ...