Biocatalyzed preparation of the optically enriched stereoisomers of 4-methyl-2-phenyl-tetrahydro-2 H-pyran (Doremox®)

E Brenna, C Fuganti, S Ronzani…

Index: Brenna, Elisabetta; Fuganti, Claudio; Ronzani, Sabrina; Serra, Stefano Canadian Journal of Chemistry, 2002 , vol. 80, # 6 p. 714 - 723

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Citation Number: 16

Abstract

The four stereoisomers of the rose oxide analogue Doremox® were prepared in enantiomerically enriched form by enantiospecific bakers' yeast reduction of suitable derivatives and by lipase-mediated kinetic resolution of diol precursors. Key words: yeast, lipase, odorant, reduction, kinetic resolution.