Synthesis and pharmacological evaluation of a new series of substituted benzoyl-γ-butyrolactone derivatives

G Cignarella, D Barlocco, D Pocar, F Clerici…

Index: Cignarella, G.; Barlocco, D.; Pocar, D.; Clerici, F.; Curzu, M. M.; et al. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 9 p. 721 - 726

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Citation Number: 3

Abstract

A series of substituted benzoyl-γ-butyrolactones (1–3) has been synthesized and tested for their ability to affect central dopaminergic and GABAergic function in comparison to γ- butyrolactone (GBL). Similarly to GBL, γ-, β-and γ-substituted GBLs 1–3 with one or more chlorine on the phenyl ring were found to induce central depressant effects in rats, though at different degrees. However, the test compounds modified dopamine (DA) metabolism in ...