Mechanism of the nitrosation of thiols and amines by oxygenated NO solutions: the nature of the nitrosating intermediates

S Goldstein, G Czapski

Index: Goldstein; Czapski Journal of the American Chemical Society, 1996 , vol. 118, # 14 p. 3419 - 3425

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Citation Number: 204

Abstract

The nitrosation of various thiols and morpholine by oxygenated NO solutions at physiological pH was investigated. The formation rates and the yields of the nitroso compounds were determined using the stopped-flow technique. The stoichiometry of this process has been determined, and is given by 4NO+ O2+ 2RSH/2RR'NH→ 2RSNO/2RR'NNO+ 2NO2-+ 2H+. Kinetic studies show that the rate law is-d [O2]/dt= k 1 [ ...