Enantioselective Enolate Protonations: Friedel–Crafts Reactions with α??Substituted Acrylates
MP Sibi, J Coulomb, LM Stanley
Index: Sibi, Mukund P.; Coulomb, Julien; Stanley, Levi M. Angewandte Chemie - International Edition, 2008 , vol. 47, # 51 p. 9913 - 9915
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Citation Number: 42
Abstract
In recent decades, enantioselective protonation of prochiral enolates has become a practical means of accessing α-chiral carbonyl compounds with high enantiomeric purity.[1] The majority of work in this area has focused on the enantioselective protonation of isolated enolate precursors, such as silyl enol ethers.[2] Silyl enol ethers derived from α-substituted cyclic ketones have been most widely studied, owing to the fixed enolate geometry ...
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