Chemistry–A European Journal

Dynamic multivalency for carbohydrate–protein recognition through dynamic combinatorial libraries based on feII–bipyridine complexes

P Reeh, J de Mendoza

Index: Reeh, Philipp; De Mendoza, Javier Chemistry - A European Journal, 2013 , vol. 19, # 17 p. 5259 - 5262

Full Text: HTML

Citation Number: 11

Abstract

Dynamic combinatorial Libraries (DCLs) have recently been employed to enhance and optimize binding affinities of carbohydrates to the surface of sugar-binding proteins (lectins),[1] as their thermodynamic equilibrium is biased towards the best-matching arrangement by simply adding the respective target.[1a, 2] It is widely accepted that multivalent presentation of binding sugar units is the method of choice for enhancing ...