Substituted Tetrahydropyrrolo [2, 1-b] oxazol-5 (6 H)-ones and Tetrahydropyrrolo [2, 1-b] thiazol-5 (6 H)-ones as Hypoglycemic Agents 1

…, B Balkan, PA Bell, LJ Brand, SH Cheon…

Index: Aicher, Thomas D.; Balkan, Bork; Bell, Philip A.; Brand, Leonard J.; Cheon; Deems, Rhonda O.; Fell, Jay B.; Fillers, William S.; Fraser, James D.; Gao, Jiaping; Knorr, Douglas C.; Kahle, Gerald G.; Leone, Christina L.; Nadelson, Jeffrey; Simpson, Ronald; Smith, Howard C. Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4556 - 4566

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Citation Number: 60

Abstract

A series of substituted tetrahydropyrrolo [2, 1-b] oxazol-5 (6 H)-ones and tetrahydropyrrolo [2, 1-b] thiazol-5 (6 H)-ones was synthesized from amino alcohols or amino thiols and keto acids. A pharmacological model based on the results obtained with these compounds led to the synthesis and evaluation of a series of isoxazoles and other monocyclic compounds. These were evaluated for their ability to enhance glucose utilization in cultured L6 ...