Antitumor Polycyclic Acridines. 20.(1) Search for DNA Quadruplex Binding Selectivity in a Series of 8, 13-Dimethylquino [4, 3, 2-kl] acridinium Salts: Telomere- …

…, C Modi, JC Cookson, I Hutchinson…

Index: Heald, Robert A.; Modi, Chetna; Cookson, Jenny C.; Hutchinson, Ian; Laughton, Charles A.; Gowan, Sharon M.; Kelland, Lloyd R.; Stevens, Malcolm F.G. Journal of Medicinal Chemistry, 2002 , vol. 45, # 3 p. 590 - 597

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Citation Number: 56

Abstract

The growth-inhibitory activities of an extensive series of quaternized quino [4, 3, 2-kl] acridinium salts against tumor cell lines in vitro have been measured and their biological properties interpreted in the light of differential binding to different DNA isoforms. Selectivity for quadruplex DNA binding and stabilization by compounds were explored through an array of methods: UV absorption and fluorescence emission spectroscopy, surface ...