Tetrahedron letters

tert-Butyldiphenylsilylamines: A useful protecting group for primary amines

LE Overman, ME Okazaki, P Mishra

Index: Overman, Larry E.; Okazaki, Mark E.; Mishra, Pratibha Tetrahedron Letters, 1986 , vol. 27, # 37 p. 4391 - 4394

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Citation Number: 46

Abstract

Summary: The utility of the tert-butyldiphenylsilyl group for protecting primary amines is explored. These derivatives are notably stable to chromatography, basic and hydrolytic reagents, as well as alkylating and acylating reagents. They are smoothly cleaved by mild acid and pyridine-HF.