… of morphine and cocaine self-administration in rats by a mixed mu antagonist-kappa agonist (N-CBM-TAMO) and a long-acting selective D 1 antagonist (AS-300)

…, JY Xu, M Teitler, A Sebastian, W El-Hamouly…

Index: Archer, Sydney; Glick, Stanley D.; Maisonneuve, Isabelle M.; Bidlack, Jean M.; Xu, Jimmy Y.; Teitler, Milt; Sebastian, Alice; El-Hamouly, Wageeh; Hutchinson, Ian Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 10 p. 1139 - 1144

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Citation Number: 6

Abstract

N-CBM-TAMO 2 was prepared by the same procedure as used for TAMO 1. It was found to be a short-term kappa agonist and a long-term mu antagonist. The benzazepine 12,(AS- 300) was a potent selective D1 antagonist. Both compounds suppressed cocaine and morphine self-administration in rats at doses which did not affect water consumption. The synthesis of N-CBM-TAMO (2) and AS-300 (12) is described. Both drugs block cocaine ...