Redox chemistry of the 9-anilinoacridine class of antitumor agents

…, A Lindsay, JE Packer, BC Baguley…

Index: Jurlina, Jeffrey L.; Lindsay, Andrew; Packer, John E.; Baguley, Bruce C.; Denny, William A. Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 473 - 480

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Citation Number: 33

Abstract

9-Anilinoacridines bearing a l'-NHR substituent on the anilino ring undergo facile, chemically reversible, two-electron oxidation to quinone diimines. The chemical and electrochemical oxidation of three groups of 9-anilinoacridines (1'-substituted derivatives, together with 3'mbstituted analogues and acridine-substituted analogues of the clinical antileukemic drug amsacrine) have been studied and their redox potentials determined. ...